منابع مشابه
miR-124-regulated RhoG
RhoG is a member of the Rho family of small GTPases sharing highest sequence similarity with Rac and Cdc42. Mig-2 and Mtl represent the functional equivalents of RhoG in Caenorhabditis elegans and Drosophila, respectively. RhoG has attracted great interest because it plays a central role in the regulation of cytoskeletal reorganization in various physiological and pathophysiological situations....
متن کاملmiR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signaling
As you can see, while there is an interest in the study there are also many concerns raised with it that I am afraid preclude publication at this stage. The referees find that further experiments are needed to demonstrate that RhoG is a direct target of miR-12, to validate the specificity of the RNAi effects, this included rescue experiments and quantifying the efficiency of the knockdown appro...
متن کاملmiR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
The small GTPase RhoG plays a central role in actin remodelling during diverse biological processes such as neurite outgrowth, cell migration, phagocytosis of apoptotic cells, and the invasion of pathogenic bacteria. Although it is known that RhoG stimulates neurite outgrowth in the rat pheochromocytoma PC12 cell line, neither the physiological function nor the regulation of this GTPase in neur...
متن کاملExpression of Flotilin-2 and Acrosome Biogenesis Are Regulated by MiR-124 during Spermatogenesis
MicroRNAs (miRNAs) are a class of short non-coding RNA molecules, which diversely regulate gene expression in organisms. Although the regulatory role of these small RNA molecules has been recently explored in animal spermatogenesis, the role of miR-124 in male germ cells is poorly defined. In our previous study, flotillin-2 was investigated as a novel Golgi-related protein involved in sperm acr...
متن کاملMethylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3
This study was to investigate the roles and mechanisms of miR-124-1 in hepatocellular carcinoma (HCC). We analyzed the expression of miR-124-1 in human HCC tissues and cell lines. Luciferase reporter assays were used to analyze the target of miR-124-1. Human HCC cell lines were transduced with lentiviruses expressing miR-124-1, and proliferation and colony formation were analyzed. The growth of...
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ژورنال
عنوان ژورنال: Small GTPases
سال: 2013
ISSN: 2154-1248,2154-1256
DOI: 10.4161/sgtp.22922